|
KMID : 0376219750120020335
|
|
Chonnam Medical Journal
1975 Volume.12 No. 2 p.335 ~ p.346
|
|
|
Effect of Guanethidine and Sympathomimetic amine infusion on the Pressor Activity of Norepinephrine, Epinephrine and Tyramine
|
|
|
|
|
Abstract
|
|
|
1. Effect of guanethidine and sympathomimetic amine infusion on the pressor activity of norepinephrine, epinephrine and tyramine was investigated in spinal rabbits. The amines infused were metaraminol, d-amphetamine, 1-norepinephrine, tyramine, 1-ephedrine, 1-phenylephrine and dl-methoxamine.
2. Guanethidine potentiated the pressor activity of norepinephrine and epinephrin but weakened that of tyramine. The infusion of the above sympathomimeti amines potentiated the pressor activity of norepinephrine and epinephrine and little affected that of tyramine.
3. The pressor activity of norepinephrine potentiated by guanethidine was not further influenced by the infusion of the above sympathomimetic amines. The pressor activity of norepinephrine potentiated by the infusion of metaraminol, d-amphetamine, 1-norepinephrine, 1-ephedrine was not further influenced by guanethidine; while that potentiated by tyramine, 1-phenylephrine and di-methoxamine was furhter increased by guanethidine.
4. The pressor activity of epinephrine potentiated by guanethidine was not further influenced by the infusion of the above sympathomimetic amines, while that potentiated by the infusion of the sympathomimetic amines was further increased by guanethidine.
5. The pressor activity of tyramine weakened by guanethidine was increased by the infusion of d-amphetamine, 1-norepinephrine and 1-ephedrine but not influenced by the other sympathomimetic amines. The pressor activity of tyramine which was not affected by the infusion of the sympathomimetic amines was markedly weakened by .guanethidine.
6. It is inferred that the potentiation of pressor activity of norepinephrine by guanethidine and the infusion of metaraminol, d-amphetamine, 1 norepi ephrine and 1-ephedrine is associated with the amine-uptake process on he adrenergic nerve endings and the state of the alpha-adrenergic receptors in the vascular smooth muscle, and that the potentiation by tyramine, 1-phenylephrine, dl-methoxamine is not associated with the amine-uptake process but the state of the alpha-adrenergic receptors.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|